The idea is: celebrities sign a pair of jeans. You buy them. Proceeds go to the National Hemophilia Foundation -- "for all bleeding and clotting disorders."
I'm not sure if the celebrities have worn these jeans, or simply signed them. For that matter, I'm not sure how their wearing them would affect the jeans' value -- that's for the market to decide (my guess: used Tyra jeans would be worth more than, say, Jay Mohr's.) Bid on a pair and see for yourself.